Ontology highlight
ABSTRACT:
SUBMITTER: Schuurs ZP
PROVIDER: S-EPMC8093007 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Schuurs Zachariah P ZP Hammond Edward E Elli Stefano S Rudd Timothy R TR Mycroft-West Courtney J CJ Lima Marcelo A MA Skidmore Mark A MA Karlsson Richard R Chen Yen-Hsi YH Bagdonaite Ieva I Yang Zhang Z Ahmed Yassir A YA Richard Derek J DJ Turnbull Jeremy J Ferro Vito V Coombe Deirdre R DR Gandhi Neha S NS
Computational and structural biotechnology journal 20210504
SARS-CoV-2 has rapidly spread throughout the world's population since its initial discovery in 2019. The virus infects cells via a glycosylated spike protein located on its surface. The protein primarily binds to the angiotensin-converting enzyme-2 (ACE2) receptor, using glycosaminoglycans (GAGs) as co-receptors. Here, we performed bioinformatics and molecular dynamics simulations of the spike protein to investigate the existence of additional GAG binding sites on the receptor-binding domain (RB ...[more]