Sirtuin 5 Is Regulated by the SCF^{Cyclin F} Ubiquitin Ligase and Is Involved in Cell Cycle Control.

ABSTRACT: The ubiquitin-proteasome system is essential for cell cycle progression. Cyclin F is a cell cycle-regulated substrate adapter F-box protein for the Skp1, CUL1, and F-box protein (SCF) family of E3 ubiquitin ligases. Despite its importance in cell cycle progression, identifying cyclin F-bound SCF complex (SCF^{Cyclin F}) substrates has remained challenging. Since cyclin F overexpression rescues a yeast mutant in the cdc4 gene, we considered the possibility that other genes that genetically modify cdc4 mutant lethality could also encode cyclin F substrates. We identified the mitochondrial and cytosolic deacylating enzyme sirtuin 5 (SIRT5) as a novel cyclin F substrate. SIRT5 has been implicated in metabolic processes, but its connection to the cell cycle i

SUBMITTER: Mills CA 

PROVIDER: S-EPMC8093487 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature