Optimizing the timing of diagnostic testing after positive findings in lung cancer screening: a proof of concept radiomics study.

ABSTRACT:

Background

The timeliness of diagnostic testing after positive screening remains suboptimal because of limited evidence and methodology, leading to delayed diagnosis of lung cancer and over-examination. We propose a radiomics approach to assist with planning of the diagnostic testing interval in lung cancer screening.

Methods

From an institute-based lung cancer screening cohort, we retrospectively selected 92 patients with pulmonary nodules with diameters ≥ 3 mm at baseline (61 confirmed as lung cancer by histopathology; 31 confirmed cancer-free). Four groups of region-of-interest-based radiomic features (n = 310) were extracted for quantitative characterization of the nodules, and eight features were proven to be predictive of cancer diagnosis, noise-robust, phenotype-relat

SUBMITTER: Wang Z 

PROVIDER: S-EPMC8094528 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature