Glomerular filtration function decline, mortality, and cardiovascular events: data from the Strong Heart Study.

ABSTRACT:

Background

Rapid kidney decline is associated with mortality and cardiovascular disease, even in the absence of chronic kidney disease. American Indians (AI) have particularly high burden of kidney disease, cardiovascular disease, and stroke. This study aims to examine extreme loss in glomerular function in this population in association with clinical outcomes.

Methods

The Strong Heart Study, a large longitudinal cohort of adult AI participants, collected plasma creatinine at 3 examination visits between 1989-1999. Intraindividual regressions of estimated glomerular filtration rate (eGFR) provided linear estimates of change in kidney function over this time period. Surveillance with physician adjudication identified mortality and cardiovascular events between visit 3 through

SUBMITTER: Suchy-Dicey AM 

PROVIDER: S-EPMC8096185 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature