Ontology highlight
ABSTRACT:
SUBMITTER: Baek K
PROVIDER: S-EPMC8096640 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Baek Kheewoong K Scott Daniel C DC Schulman Brenda A BA
Current opinion in structural biology 20201105
RING E3s comprise the largest family of ubiquitin (UB) and ubiquitin-like protein (UBL) ligases. RING E3s typically promote UB or UBL transfer from the active site of an associated E2 enzyme to a distally-recruited substrate. Many RING E3s - including the cullin-RING ligase family - are multifunctional, interacting with various E2s (or other E3s) to target distinct proteins, transfer different UBLs, or to initially modify substrates with UB or subsequently elongate UB chains. Here we consider re ...[more]