Influence of fine particulate matter and its pure particulate fractions on pulmonary immune cells and cytokines in mice.

ABSTRACT: Particulate matter with a diameter ≤2.5 µm (PM^2.5) has a complex composition and has been associated with the incidence of cardiopulmonary disease and premature death in humans. However, whether pure particulate fractions of PM^2.5 (PPP^2.5), which are composed primarily of carbon, are responsible for the toxicity caused by ambient particulate matter (original PM^2.5 particles, OPP^2.5) is currently unclear. The present study assessed the acute toxic effects of OPP^2.5 sampled in Beijing, China and of its PPP^2.5 fraction in male BALB/c mice. The mice were intratracheally instilled with a single dose of aerosolized OPP^2.5 or PPP^2.5. Blood, lungs and bronchoalveolar lavage fluid were collected after

SUBMITTER: Jiao Z 

PROVIDER: S-EPMC8097186 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature