Ontology highlight
ABSTRACT:
SUBMITTER: Zhao H
PROVIDER: S-EPMC8097437 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Zhao Hongliang H Eszterhas Susan S Furlon Jacob J Cheng Hao H Griswold Karl E KE
Antimicrobial agents and chemotherapy 20210318 4
Drug-resistant bacterial pathogens are a serious threat to global health, and antibacterial lysins are at the forefront of innovative treatments for these life-threatening infections. While lysins' general mechanism of action is well understood, the design principles that might enable engineering of performance-enhanced variants are still being formulated. Here, we report a detailed analysis of molecular determinants underlying the <i>in vivo</i> efficacy of lysostaphin, a canonical anti-MRSA (m ...[more]