Z-Selective Dienylation Enables Stereodivergent Construction of Dienes and Unravels a Ligand-Driven Mechanistic Dichotomy.

ABSTRACT: Development of stereoselective and efficient reactions for construction of conjugated dienes and polyenes has remained at the forefront of organic chemistry, due to their key roles in medicinal chemistry, organic synthesis, and materials science. The synthesis of conjugated dienes and polyenes is typically accomplished in a multistep manner by sequential installation of individual C=C bonds because it allows for control of stereoselectivity and efficiency of formation of each double bond. A conceptually distinct dienylation approach entails a stereoselective appendage of a four-carbon unit, shortcutting diene synthesis. Dienylation with sulfolene provided a direct route to E-dienes, but the synthesis of substantially more challenging Z-dienes remained elusive. Here, we report

SUBMITTER: Dang HT 

PROVIDER: S-EPMC8098720 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature