Ontology highlight
ABSTRACT:
SUBMITTER: Li N
PROVIDER: S-EPMC8099426 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Li Na N Zhao Shangang S Zhang Zhuzhen Z Zhu Yi Y Gliniak Christy M CM Vishvanath Lavanya L An Yu A YA Wang May-Yun MY Deng Yingfeng Y Zhu Qingzhang Q Shan Bo B Sherwood Amber A Onodera Toshiharu T Oz Orhan K OK Gordillo Ruth R Gupta Rana K RK Liu Ming M Horvath Tamas L TL Dixit Vishwa Deep VD Scherer Philipp E PE
eLife 20210427
Adiponectin is essential for the regulation of tissue substrate utilization and systemic insulin sensitivity. Clinical studies have suggested a positive association of circulating adiponectin with healthspan and lifespan. However, the direct effects of adiponectin on promoting healthspan and lifespan remain unexplored. Here, we are using an adiponectin null mouse and a transgenic adiponectin overexpression model. We directly assessed the effects of circulating adiponectin on the aging process an ...[more]