Transcription factor networks of oligodendrogliomas treated with adjuvant radiotherapy or observation inform prognosis.

ABSTRACT:

Background

Recent international sequencing efforts have allowed for the molecular taxonomy of lower-grade gliomas (LGG). We sought to analyze The Cancer Genome Atlas (TCGA, 2015) gene expression datasets on molecularly defined oligodendrogliomas (IDH-mutated and 1p/19q-codeleted) patients treated with adjuvant radiation or those observed to discover prognostic markers and pathways.

Methods

mRNA expression and clinical information of patients with oligodendroglioma were taken from the TCGA "Brain Lower Grade Glioma" provisional dataset. Transcription factor network reconstruction and analysis were performed using the R packages "RTN" and "RTNsurvival." Elastic net regularization and survival modeling were performed using the "biospear," "plsRCox," "survival" packages.

Resu

SUBMITTER: So J 

PROVIDER: S-EPMC8099467 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature