Accuracy analysis of dam deformation monitoring and correction of refraction with robotic total station.
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ABSTRACT:
SUBMITTER: Zhou J
PROVIDER: S-EPMC8101930 | biostudies-literature |
REPOSITORIES: biostudies-literature
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Project description:PurposeRefraction, as measured by spherical equivalent, is the need for an external lens to focus images on the retina. While genetic factors play an important role in the development of refractive errors, few susceptibility genes have been identified. However, several regions of linkage have been reported for myopia (2q, 4q, 7q, 12q, 17q, 18p, 22q, and Xq) and for quantitative refraction (1p, 3q, 4q, 7p, 8p, and 11p). To replicate previously identified linkage peaks and to identify novel loci that influence quantitative refraction and refractive errors, linkage analysis of spherical equivalent, myopia, and hyperopia in the Beaver Dam Eye Study was performed.MethodsNonparametric, sibling-pair, genome-wide linkage analyses of refraction (spherical equivalent adjusted for age, education, and nuclear sclerosis), myopia and hyperopia in 834 sibling pairs within 486 extended pedigrees were performed.ResultsSuggestive evidence of linkage was found for hyperopia on chromosome 3, region q26 (empiric P = 5.34 × 10(-4)), a region that had shown significant genome-wide evidence of linkage to refraction and some evidence of linkage to hyperopia. In addition, the analysis replicated previously reported genome-wide significant linkages to 22q11 of adjusted refraction and myopia (empiric P = 4.43 × 10(-3) and 1.48 × 10(-3), respectively) and to 7p15 of refraction (empiric P = 9.43 × 10(-4)). Evidence was also found of linkage to refraction on 7q36 (empiric P = 2.32 × 10(-3)), a region previously linked to high myopia.ConclusionsThe findings provide further evidence that genes controlling refractive errors are located on 3q26, 7p15, 7p36, and 22q11.
| S-EPMC3176073 | biostudies-literature
Project description:Electrical methods are among the primarily studied non-invasive glucose measurement techniques; however, various factors affect the accuracy of the sensors used. Of these, the temperature is a critical factor; hence, the effects of temperature on the electrical properties of blood components are investigated in this study. Furthermore, the changes in the electrical properties of blood according to the glucose level are corrected by considering the effects of temperature on the electrical properties. An impedance sensor is developed and used to measure whole blood impedance in 10 healthy participants at various temperatures and glucose levels. Subsequently, the conductivities of the plasma and cytoplasm were extracted. Changes in the electrical properties of the blood components are then analyzed using linear regression and repeated measures ANOVA. The electrical conductivities of plasma and cytoplasm increased with increasing temperatures (plasma: 0.0397 (slope), 0.7814 (R2), cytoplasm: 0.014 (slope), 0.694 (R2)). At three values of increasing glucose levels (85.4, 158.1, and 271.8 mg/dL), the electrical conductivities of the plasma and cytoplasm decreased. These tendencies are more significant upon temperature corrections (p-values; plasma: 0.001, 0.001, cytoplasm: 0.003, 0.002). The relationships between temperature and electrical conductivity changes can thus be used for temperature corrections in blood glucose measurement.
| S-EPMC7663582 | biostudies-literature
Project description:SIGNIFICANCE:Uncorrected refractive error is a prevalent problem throughout the world especially among the low-income population who have limited access to professional eye care and cannot afford eyeglasses. PURPOSE:The purpose of this study was to evaluate the accuracy and usability of a low-cost, portable, smartphone-based autorefractor (Netra, EyeNetra Inc., Somerville, MA) in adults. METHODS:A cross-sectional study was conducted to compare the portable refractor with subjective (manifest and cycloplegic) refraction for sequential adult participants with best-corrected visual acuity of 20/40 or greater. For each method of refraction, the spherical equivalent was calculated. Differences between methods were tested with linear mixed regression models. A validated usability questionnaire was administered regarding ease of use (100-point scale, higher scores better) for the portable autorefractor. RESULTS:Eighty-seven subjects (152 eyes) were studied (age range, 20 to 90 years; mean ± standard deviation, 51.9 ± 18.3 years). Mean spherical equivalent by the portable device was -2.76 D (range, -14.75 to 3.63 D) compared with -2.49 D (range, -15.25 to 4.25 D) by manifest refraction. The mean relative difference in spherical equivalent between methods was -0.27 D (P = .001, significantly different than 0 D). The mean absolute difference between methods was 0.69 D (P < .001, significantly different than 0.5-D absolute difference). Similar results were found when comparing spherical equivalent between Netra and cycloplegic refraction methods. Subjects reported average ease of use for the Netra of 75.4 ± 19.8. CONCLUSIONS:The portable autorefractor had small but clinically significant differences from subjective refraction. The device's scores on the usability scale indicate good overall patient acceptance. The device may be valuable for use where there is limited access to a trained refractionist.
| S-EPMC6475906 | biostudies-literature
Project description:BackgroundAmong postsurgical and critically ill patients, malglycemia is associated with increased complications. Continuous glucose monitoring (CGM) in the inpatient population may enhance glycemic control. CGM reliability may be compromised by postsurgical complications such as edema or vascular changes. We utilized Clarke Error Grid (CEG) and Surveillance Error Grid (SEG) analysis to evaluate CGM performance after total pancreatectomy with islet autotransplantation.Materials and methodsThis subanalysis evaluated Medtronic Enlite 2 CGM values against YSI serum glucose in seven post-transplant patients (86% female; 38.6 ± 9.4 years) on artificial pancreas for 72 h at transition from intravenous to subcutaneous insulin. Sensor recalibration occurred for absolute relative difference (ARD) ≥20% x2, ≥30% x1, or by investigator discretion based on trend.ResultsSensor analysis showed mean absolute relative difference (MARD) of 11.0% ± 11.5%. The sensors were recalibrated 8.3 times/day; active sensor was switched 1.4 times/day. Calibration factor was 7.692 ± 3.786 mg/nA·dL (target = 1.5-20 mg/nA·dL). CEG analysis showed 86.1% of pairs in Zone A (clinically accurate zone) and 99.4% of pairs in Zones A + B (low risk of error). SEG analysis of hypoglycemia/hyperglycemia risk showed 92.22% of pairs in the "no risk" zone, 5.96% of pairs in the "slight lower" risk zone, 1.01% of pairs in the "slight higher" risk zone, and only 0.81% of pairs in the "moderate lower" risk zone.ConclusionsOverall performance of the Medtronic Enlite 2 CGM in the post-transplant population was reasonably good with "no risk" or "slight lower" risk by SEG analysis and high CGM-YSI agreement by CEG analysis; however, frequent recalibrations were required in this intensive care population.
| S-EPMC4991614 | biostudies-literature
Project description:Purpose Total knee arthroplasty (TKA) is widely recognized as an effective treatment for end-stage knee osteoarthritis (OA). Compared with conventional TKA, robotic-arm assisted TKA may improve patients’ functionality and resulting quality of life by more accurate and precise component placement. Currently, the literature on cost-effectiveness of robotic-arm assisted TKA in the US is limited. The objective of this study was to assess the cost-effectiveness of robotic-arm assisted TKA relative to TKA in the Medicare-aged population including exploring the impact of hospital volume on cost-effectiveness outcomes. Methods We developed a decision-analytic model to evaluate the costs, health outcomes, and incremental cost-effectiveness ratio (ICER) of robotic-arm assisted TKA vs TKA in Medicare population with OA. We evaluated cost-effectiveness at a willingness-to-pay (WTP) threshold of $50,000 per quality-adjusted life-year (QALY). We sourced costs from the literature including episode-of-care (EOC) costs from a Medicare study. We assessed cost-effectiveness of robotic-arm assisted TKA by hospital procedure volume and conducted deterministic (DSA) and probabilistic sensitivity analysis (PSA). Results For the average patient treated in a hospital with an annual volume of 50 procedures, robotic-arm assisted TKA resulted in a total QALY of 6.18 relative to 6.17 under conventional TKA. Total discounted costs per patient were $32,535 and $31,917 for robotic-arm assisted TKA and conventional TKA, respectively. Robotic-arm assisted TKA was cost-effective in the base case with an ICER of $41,331/QALY. In univariate DSA, cost-effectiveness outcomes were most sensitive to the annual hospital procedure volume. Robotic-arm assisted TKA was cost-effective at a WTP of $50,000/QALY only when hospital volume exceeded 49 procedures per year. In PSA, robotic-arm assisted TKA was cost-effective at a $50,000/QALY WTP threshold in 50.4% of 10,000 simulations. Conclusions Despite high robotic purchase costs, robotic-arm assisted TKA is likely to be cost-effective relative to TKA in the Medicare population with knee OA in high-volume hospitals through lowering revision rates and decreasing post-acute care costs. Higher-volume hospitals may deliver higher value in performing in robotic-arm assisted TKA.
| S-EPMC9704609 | biostudies-literature
Project description:Due to ever increasing precision and automation demands in robotic grinding, the automatic and robust robotic grinding workstation has become a research hot-spot. This work proposes a grinding workstation constituting of machine vision and an industrial manipulator to solve the difficulty of positioning rough metal cast objects and automatic grinding. Faced with the complex characteristics of industrial environment, such as weak contrast, light nonuniformity and scarcity, a coarse-to-fine two-step localization strategy was used for obtaining the object position. The deep neural network and template matching method were employed for determining the object position precisely in the presence of ambient light. Subsequently, edge extraction and contour fitting techniques were used to measure the position of the contour of the object and to locate the main burr on its surface after eliminating the influence of burr. The grid method was employed for detecting the main burrs, and the offline grinding trajectory of the industrial manipulator was planned with the guidance of the coordinate transformation method. The system greatly improves the automaticity through the entire process of loading, grinding and unloading. It can determine the object position and target the robotic grinding trajectory by the shape of the burr on the surface of an object. The measurements indicate that this system can work stably and efficiently, and the experimental results demonstrate the high accuracy and high efficiency of the proposed method. Meanwhile, it could well overcome the influence of the materials of grinding work pieces, scratch and rust.
| S-EPMC7990196 | biostudies-literature
Project description:Radar Interferometry is a widely used method for estimating ground deformation, as it provides precision to a few millimeters to centimeters, and at the same time, a wide spatial coverage of the study area. On July 9, 1956, one of the strongest earthquakes of the 20th century in the area of the South Aegean, occurred in Amorgos, with a magnitude of Mw = 7.7. The objective of this research is to map ground deformation in Amorgos island, using InSAR techniques. We conducted a multi-temporal analysis of all available data from 2003 to 2019 by exploiting historical ENVISAT SAR imagery, as well as the dense archive of Sentinel-1 SLC imagery. Persistent Scatterer Interferometry (PS) and Small Baseline Subset (SBAS) methods were implemented. Results of both data-sets indicate a small-scale deformation on the island. A multi-track analysis was implemented on Sentinel-1 data to decompose the line of sight velocities to vertical and horizontal. The central south coast is experiencing horizontal movement, while uplift of a maximum value of 5 mm/y is observed in the southeastern coast. The combination of the good spatial coverage achievable via InSAR, with GPS measurements, is suggested an important tool for the seamless monitoring of Amorgos island towards tectonic hazard estimation.
| S-EPMC7014404 | biostudies-literature
Project description:BackgroundAccurate cup placement during total hip arthroplasty (THA) is difficult because the intraoperative pelvic position changes even in supine patient position. We developed a device known as HipPointer; it corrects pelvic rotation and creates a functional pelvic plane as a reference. The aim of this study was to determine the device placement accuracy and investigate causes of error.Material and methodsHipPointer was used for cup placement in 353 hips of 308 patients who underwent direct-anterior-approach THA in supine position. The mean age at surgery and body mass index were 63.9 (17-90) years and 24.9 (16.6-42.0) kg/m2, respectively. The mean observation period was 40.5 (12-73) months. To investigate the accuracy of HipPointer, preoperative planning and postoperative cup placement angles relative to the functional pelvic plane were evaluated using a three-dimensional analysis software, and absolute errors were determined.ResultsThe means ± standard deviations of radiographic inclination (RI) and radiographic anteversion (RA) were 40.2 ± 3.0° and 15.8 ± 3.6°, respectively. The absolute errors of RI and RA were 2.2 ± 2.0° and 2.7 ± 2.3°, respectively. The ratio of the cup placement angle for which both RI and RA are ≤10° in the target zone was 99% (350/353 hips), and the ratio of the absolute errors for which both RI and RA are ≤5° was 80.4% (284/353 hips).ConclusionsHipPointer is simple in structure, easy to use, and useful for direct-anterior-approach THA in supine position. It provides good cup placement accuracy.
| S-EPMC9133511 | biostudies-literature
Project description:The multiplexing capabilities of isobaric mass tag based protein quantification, such as Tandem Mass Tags (TMT) or Isobaric Tag for Relative and Absolute Quantitation (iTRAQ) have dramatically increased the scope of Mass Spectrometry (MS) based proteomics studies. Not only does the technology allow for the simultaneous quantification of multiple samples in a single MS injection, but its seamless compatibility with extensive sample pre-fractionation methods allow for comprehensive study of complex proteomes. However, reporter ion based quantification has often been criticized for limited quantification accuracy due to interference from co-eluting peptides and peptide fragments. In this study, we investigate the extent of this problem and propose an effective and easy-to-implement remedy relying on spiking a 6-protein calibration mixture to the samples subject to relative quantification. Our ratio adjustment approach was evaluated on a large scale TMT 10-plex dataset derived from cancer cell lines with chromosome instability. Furthermore, we analyzed a complex 2-proteome artificial sample mixture and investigated the precision of TMT and precursor ion intensity based Label Free Quantification. Comparing the two methods we observed that the isobaric tag based quantification workflow, due to its superior precision, was able to confirm more and smaller protein abundance changes, at a fixed False Positive Rate.
2016-07-01 | PXD003346 | Pride
Project description:Collecting a myriad of prototype data through various types of monitoring sensors plays a virtual important role in many aspects of dam safety such as real-time grasp of safety state, exposure of hidden dangers, and inspection design and construction. However, the current methods of prediction are weak in the long-term sequence of nodes with missing and abnormal error value. Moreover, the limitation caused by the apparatus, environmental factors, and network transmission can lead to the deviation and inconsistency of diagnosis and evaluation of local region. In this paper, we consider the correlation of data on nodes in the entire monitoring network. To avoid the deviation caused by noise and missing value in the single-node data sequence, we calculate the correlation between the multiple sequences. A single-node assessment model based on multiple relevant sequence (SAM) is proposed to improve the accuracy of single node assessment. Given the different nodes of a local region have varying impacts on the evaluation results, a local region evaluation algorithm based on node credibility (LREA) is presented to model the credibility of nodes in order to alleviate inconsistent evaluation results in the local region of dam. LREA can assess the dam's operation state by considering the variations in credibility and multiple nodes coordination. The experimental results illustrate the LREA can reveal the trends of the monitoring values change in a timely and accurate way, which can elevate the accuracy of evaluation results of dam safety.
| S-EPMC7915524 | biostudies-literature