Targeting the biology of ageing with mTOR inhibitors to improve immune function in older adults: phase 2b and phase 3 randomised trials.
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ABSTRACT:
SUBMITTER: Mannick JB
PROVIDER: S-EPMC8102040 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
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Targeting the biology of ageing with mTOR inhibitors to improve immune function in older adults: phase 2b and phase 3 randomised trials.
Mannick Joan B JB Teo Grace G Bernardo Patti P Quinn Dean D Russell Kerry K Klickstein Lloyd L Marshall William W Shergill Sarb S
The lancet. Healthy longevity 20210506 5
<h4>Background</h4>The COVID-19 pandemic highlights the need for therapies that improve immune function in older adults, including interferon (IFN)-induced antiviral immunity that declines with age. In a previous phase 2a trial, RTB101 (previously known as BEZ235), an oral mechanistic target of rapamycin (mTOR) inhibitor, was observed to increase IFN-induced antiviral gene expression and decrease the incidence of respiratory tract infections (RTIs) in older adults. Therefore, we aimed to investi ...[more]
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