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Do caffeine and more selective adenosine A2A receptor antagonists protect against dopaminergic neurodegeneration in Parkinson's disease?


ABSTRACT: The adenosine A2A receptor is a major target of caffeine, the most widely used psychoactive substance worldwide. Large epidemiological studies have long shown caffeine consumption is a strong inverse predictor of Parkinson's disease (PD). In this review, we first examine the epidemiology of caffeine use vis-à-vis PD and follow this by looking at the evidence for adenosine A2A receptor antagonists as potential neuroprotective agents. There is a wealth of accumulating biological, epidemiological and clinical evidence to support the further investigation of selective adenosine A2A antagonists, as well as caffeine, as promising candidate therapeutics to fill the unmet need for disease modification of PD.

SUBMITTER: Chen JF 

PROVIDER: S-EPMC8102090 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Do caffeine and more selective adenosine A<sub>2A</sub> receptor antagonists protect against dopaminergic neurodegeneration in Parkinson's disease?

Chen Jiang-Fan JF   Schwarzschild Michael A MA  

Parkinsonism & related disorders 20201101


The adenosine A<sub>2A</sub> receptor is a major target of caffeine, the most widely used psychoactive substance worldwide. Large epidemiological studies have long shown caffeine consumption is a strong inverse predictor of Parkinson's disease (PD). In this review, we first examine the epidemiology of caffeine use vis-à-vis PD and follow this by looking at the evidence for adenosine A<sub>2A</sub> receptor antagonists as potential neuroprotective agents. There is a wealth of accumulating biologi  ...[more]

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