Ontology highlight
ABSTRACT:
SUBMITTER: Chen JF
PROVIDER: S-EPMC8102090 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Chen Jiang-Fan JF Schwarzschild Michael A MA
Parkinsonism & related disorders 20201101
The adenosine A<sub>2A</sub> receptor is a major target of caffeine, the most widely used psychoactive substance worldwide. Large epidemiological studies have long shown caffeine consumption is a strong inverse predictor of Parkinson's disease (PD). In this review, we first examine the epidemiology of caffeine use vis-à-vis PD and follow this by looking at the evidence for adenosine A<sub>2A</sub> receptor antagonists as potential neuroprotective agents. There is a wealth of accumulating biologi ...[more]