Seven-gene signature on tumor microenvironment for predicting the prognosis of patients with pancreatic cancer.

ABSTRACT:

Background

The aim of the present study was to construct a novel gene signature on the tumor microenvironment (TME) to predict the prognosis of patients with pancreatic ductal adenocarcinoma (PDAC).

Methods

We downloaded gene expression profiles and clinical information of PDAC from The Cancer Genome Atlas (TCGA) datasets, as well as Gene Expression Omnibus (GEO) datasets (GSE78229, GSE62452, and GSE28735). Differentially expressed genes were generated by comparing high versus low score groups of immune/stromal subgroups based on the Estimation of STromal and Immune cells in MAlignant Tumor tissues using Expression data algorithm. Subsequently, a prognostic risk score model was constructed and validated through univariate and multivariate Cox regression analyses. Finally, fu

SUBMITTER: Yang B 

PROVIDER: S-EPMC8102236 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature