Stress-induced cortisol response is associated with right amygdala volume in early childhood.

ABSTRACT: Rodent research suggests that dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis and the resulting cortisol stress response can alter the structure of the hippocampus and amygdala. Because early-life changes in brain structure can produce later functional impairment and potentially increase risk for psychiatric disorder, it is critical to understand the relationship between the cortisol stress response and brain structure in early childhood. However, no study to date has characterized the concurrent association between cortisol stress response and hippocampal and amygdala volume in young children. In the present study, 42 young children (M _age  = 5.97, SD = 0.76), completed a frustration task and cortisol response to stress was measured. Children

SUBMITTER: Fowler CH 

PROVIDER: S-EPMC8102621 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature