Dietary conjugated linoleic acid links reduced intestinal inflammation to amelioration of CNS autoimmunity.

ABSTRACT: A close interaction between gut immune responses and distant organ-specific autoimmunity including the CNS in multiple sclerosis has been established in recent years. This so-called gut-CNS axis can be shaped by dietary factors, either directly or via indirect modulation of the gut microbiome and its metabolites. Here, we report that dietary supplementation with conjugated linoleic acid, a mixture of linoleic acid isomers, ameliorates CNS autoimmunity in a spontaneous mouse model of multiple sclerosis, accompanied by an attenuation of intestinal barrier dysfunction and inflammation as well as an increase in intestinal myeloid-derived suppressor-like cells. Protective effects of dietary supplementation with conjugated linoleic acid were not abrogated upon microbiota eradication, indicating

SUBMITTER: Fleck AK 

PROVIDER: S-EPMC8105041 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature