YAP inhibits autophagy and promotes progression of colorectal cancer via upregulating Bcl-2 expression.
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ABSTRACT:
SUBMITTER: Jin L
PROVIDER: S-EPMC8105309 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
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YAP inhibits autophagy and promotes progression of colorectal cancer via upregulating Bcl-2 expression.
Jin Lan L Chen Yunhe Y Cheng Dan D He Zhikai Z Shi Xinyi X Du Boyu B Xi Xueyan X Gao Yujing Y Guo Yang Y
Cell death & disease 20210507 5
Colorectal cancer (CRC) is one of the most aggressive and lethal cancers. The role of autophagy in the pathobiology of CRC is intricate, with opposing functions manifested in different cellular contexts. The Yes-associated protein (YAP), a transcriptional coactivator inactivated by the Hippo tumor-suppressor pathway, functions as an oncoprotein in a variety of cancers. In this study, we found that YAP could negatively regulate autophagy in CRC cells, and consequently, promote tumor progression o ...[more]
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