Ontology highlight
ABSTRACT:
SUBMITTER: Bennett JEM
PROVIDER: S-EPMC8105414 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Bennett James E M JEM Philippides Andrew A Nowotny Thomas T
Nature communications 20210507 1
Effective decision making in a changing environment demands that accurate predictions are learned about decision outcomes. In Drosophila, such learning is orchestrated in part by the mushroom body, where dopamine neurons signal reinforcing stimuli to modulate plasticity presynaptic to mushroom body output neurons. Building on previous mushroom body models, in which dopamine neurons signal absolute reinforcement, we propose instead that dopamine neurons signal reinforcement prediction errors by u ...[more]