Unknown

Dataset Information

0

Apoferritin improves motor deficits in MPTP-treated mice by regulating brain iron metabolism and ferroptosis.


ABSTRACT: Iron deposition is one of the key factors in the etiology of Parkinson's disease (PD). Iron-free-apoferritin has the ability to store iron by combining with a ferric hydroxide-phosphate compound to form ferritin. In this study, we investigated the role of apoferritin in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mice models and elucidated the possible underlying mechanisms. Results showed that apoferritin remarkably improved MPTP-induced motor deficits by rescuing dopaminergic neurodegeneration in the substantia nigra. Apoferritin inhibited MPTP-induced iron aggregation by down-regulating iron importer divalent metal transporter 1 (DMT1). Meanwhile, we also showed that apoferritin prevented MPTP-induced ferroptosis effectively by inhibiting the up-regulation of long-chain acyl-CoA synthetase 4 (ACSL4) and the down-regulation of ferroptosis suppressor protein 1 (FSP1). These results indicate that apoferritin exerts a neuroprotective effect against MPTP by inhibiting iron aggregation and modulating ferroptosis. This provides a promising therapeutic target for the treatment of PD.

SUBMITTER: Song LM 

PROVIDER: S-EPMC8105649 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC8764058 | biostudies-literature
| S-EPMC7288933 | biostudies-literature
| S-EPMC8452727 | biostudies-literature
| S-EPMC5996129 | biostudies-literature
| S-EPMC2730829 | biostudies-literature
| S-EPMC7206124 | biostudies-literature
| S-EPMC1959463 | biostudies-literature
| S-EPMC6372990 | biostudies-literature
| S-EPMC6629723 | biostudies-literature
| S-EPMC7205875 | biostudies-literature