Ontology highlight
ABSTRACT:
SUBMITTER: Inoue M
PROVIDER: S-EPMC8105669 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Inoue Minoru M Enomoto Masahiro M Yoshimura Michio M Mizowaki Takashi T
Redox biology 20210426
In addition to its function of innate immunity against invading pathogens, neutrophil extracellular traps (NETs) promote thrombosis, autoimmune disease, and cancer metastasis; therefore, unnecessary exposure to the triggers of infection-independent NET generation should be avoided. We herein show that inhibition of forward-mode Na<sup>+</sup>/Ca<sup>2+</sup> exchange by amiloride analogs, 5-(N-ethyl-N-isopropyl)amiloride (EIPA) and 5-(N-Methyl-N-isobutyl)amiloride (MIA), triggers NETotic cell de ...[more]