Dataset Information

A four-year observation of corneal densitometry after implantable collamer lens V4c implantation.

ABSTRACT:

Background

To observe the changes in corneal densitometry (CD) with a Pentacam after implantable collamer lens (ICL) V4c implantation in myopia patients, and to investigate potential influencing factors.

Methods

We reviewed 65 eyes of 33 patients (mean age, 29.08±5.54 years) with myopia or myopic astigmatism who underwent ICL V4c implantation. Clinic parameters and Pentacam images of corneal topography and CD were obtained pre- and postoperatively.

Results

After an average of 52±2.2 months follow-up, the efficacy and safety indexes assessed at the last follow-up were 1.03±0.18 and 1.21±0.21, respectively. Except in the central annular zone of 0-2 mm, the CD values increased significantly at postoperative day 1 and decreased significantly until postoperative 1 year (P<0.05). The increase in CD values at different annular zones at postoperative day 1 was ranked as: 0-2 mm <2-6 mm < 6-10 mm. No significant difference was observed in corneal density at 1 week, 1 month, and 1-year follow-up when compared with the preoperative value (P>0.05). The CD value at 4 years follow-up increased significantly and correlated positively with age and preoperative uncorrected distance visual acuity, and negatively with preoperative spherical equivalent and intraocular pressure (IOP) (P<0.05).

Conclusions

ICL V4c implantation demonstrated safety and efficacy for myopia correction. The CD value increased at 4 years postoperatively and correlated with age, preoperative spherical equivalent, uncorrected distance visual acuity, and IOP.

SUBMITTER: Zhao J

PROVIDER: S-EPMC8105832 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature

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Publications

A four-year observation of corneal densitometry after implantable collamer lens V4c implantation.

Zhao Jing J Yang Wen W Zhao Jiao J Shen Yang Y Sun Ling L Han Tian T Wang Xiaoying X Yao Peijun P Zhou Xingtao X

Annals of translational medicine 20210401 7

<h4>Background</h4>To observe the changes in corneal densitometry (CD) with a Pentacam after implantable collamer lens (ICL) V4c implantation in myopia patients, and to investigate potential influencing factors.<h4>Methods</h4>We reviewed 65 eyes of 33 patients (mean age, 29.08±5.54 years) with myopia or myopic astigmatism who underwent ICL V4c implantation. Clinic parameters and Pentacam images of corneal topography and CD were obtained pre- and postoperatively.<h4>Results</h4>After an average ...[more]

PMID: 33987234

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Project description:BACKGROUND:Corneal densitometry, which is also known as corneal backscattering, is a surrogate measure of corneal clarity. The purpose of the study was to investigate the changes in corneal densitometry (CD) after implanting an implantable collamer lens (ICL-V4c). METHOD:Twenty-six high myopic patients (aged 29.3?±?6.6?years, 6 males and 20 females) who underwent ICL-V4c implantation were enrolled. Intraocular pressure (IOP), corneal topography, corneal densitometry, uncorrected distance visual acuity (UCDVA), manifest refraction, and best corrected distance visual acuity (BCDVA) were evaluated pre-operatively and at 1?day, 1?week, and 1, 3, 6, and 12?months post-operatively. Endothelial cell density (ECD) was measured pre-operatively and at 3, 6, and 12?months post-operatively. The efficacy index (mean post-operative UCDVA / mean pre-operative BCDVA) and the safety index (mean post-operative BCDVA / mean pre-operative BCDVA) were evaluated at 1?month, 3?months, 6?months and 12?months post-operatively. RESULTS:Over the annular diameters of 0-2?mm, the pre-operative densitometry values of the anterior layer, central layer, posterior layer, and total layer were 20.1?±?2.8, 11.8?±?1.1, 10.5?±?0.9 and 14.1?±?1.5, respectively. From pre-operatively to post-operative Month 12, the values changed insignificantly (P?=?0.177, P?=?0.153, P?=?0.543 and P?=?0.207, respectively). Over the annular diameters of 2-6?mm, the pre-operative mean densitometry values were 17.9?±?2.2, 10.5?±?0.9, and 12.6?±?1.2, respectively. From pre-operatively to post-operative Month 12, the values decreased to 16.5?±?2.1, 10.0?±?0.9, and 11.9?±?1.2, respectively, which were similar to the pre-operative values (all P?>?0.05) but significantly lower than the values obtained at post-operative Day 1 (P?=?0.013, P?=?0.002 and P?=?0.010, respectively). The densitometry value of the posterior layer over the annular diameters of 2 to 6?mm remained unchanged (from 9.4?±?0.7 to 9.1?±?0.7) over time (P?=?0.372). The efficacy and safety indices assessed at 12?months post-operatively were 1.04?±?0.27 and 1.19?±?0.23, respectively. The changes in IOP and ECD values were statistically insignificant (P?=?0.896 and P?=?0.968, respectively). CONCLUSION:ICL-V4c implantation may be safe and efficient for high ametropia correction. The corneal densitometry values obtained over the annulus of 0-6?mm increased slightly from before the operation to post-operative Day 1 and then decreased gradually, which indicates that ICL-V4c implantation may not compromise corneal clarity.

Project description:PurposeTo explore early changes in circumferential anterior segment structures following Implantable Collamer Lens (ICL) V4c implantation via swept-source optical coherence tomography (SS-OCT).MethodsIn 103 eyes of 56 myopic patients undergoing ICL V4c surgery, anterior segments were measured via SS-OCT to compute local anterior chamber angle (ACA) parameters on the nasal-temporal (0°-180°), superior-inferior (90°-270°), and superior nasal-inferior temporal (80°-260°) meridians, including angle-opening distance at 500 µm (AOD500), trabecular-iris space area at 500 µm (TISA500), trabecular-iris angle at 500 µm (TIA500), and circumferential ACA parameters, including AOD area at 500 µm (AODA500), trabecular-iris circumference volume at 500 µm (TICV500), and the index and area of iris-trabecular contact (ITC). ACA parameters were compared preoperatively and at 1 week, 1 month, and 3 months postoperatively and compared among quadrants. Mixed-effects model was used to evaluate the parameters correlated with the post-ITC parameters.ResultsThe mean AOD500, TISA500, TIA500, AODA500, and TICV500 were decreased by 65.4% to 71%, 64.1% to 69.3%, 53.8% to 61.5%, 69.9%, and 69.2%, respectively, at 1 week postoperatively. The ITC index and area values rose from 1.436% ± 4.427% and 0.070 ± 0.254 mm2 to 12.343% ± 13.216% and 0.903 ± 1.304 mm2 (all P < 0.05). No further decreases in ACA parameters were observed beyond 1 week postoperatively (all P > 0.05). Significant differences were observed among quadrants, with the narrowest in the superior-nasal quadrant, followed by the superior quadrant. The 3-month vault was significantly correlated with the ITC index and area at 3 months postoperatively.ConclusionsAnterior segment structures were significantly shallow at 1 week with no further decreases thereafter. In light of anatomical variability, we recommend circumferential meridian scan to assess angle status, with special attention to the superior-nasal and superior quadrants.Translational relevanceWe investigated the early changes in circumferential anterior segment structures following ICL V4c implantation, thus providing a better perspective for understanding anterior segment structural characteristics after ICL V4c surgery.

Project description:AimTo investigate the long-term safety, efficacy, and binocular balance of monovision surgery using Implantable Collamer Lens (ICL) V4c implantation and Femtosecond Laser-Assisted in situ Keratomileusis (FS-LASIK) for the treatment of myopic patients with presbyopia.MethodsThis case series study involved 90 eyes of 45 patients (male/female = 19/26; average age:46.27 ± 5.54 years; average follow-up time:48.73 ± 14.65 months) who underwent the aforementioned surgery to treat myopic presbyopes. Data on manifest refraction, corrected distance visual acuity, dominant eye, presbyopic addition, intraocular pressure, and anterior segment biometric parameters were collected. The visual outcomes and binocular balance at 0.4 m, 0.8 m, and 5 m were documented.ResultsThe safety index for the ICL V4c and FS-LASIK groups were 1.24 ± 0.27 and 1.04 ± 0.20 (p = 0.125), respectively. Binocular visual acuity (logmar) for 0.4 m, 0.8 m, and 5 m were -0.03 ± 0.05, -0.03 ± 0.02, and 0.10 ± 0.03 for the ICL V4c group, and -0.02 ± 0.09, -0.01 ± 0.02, and 0.06 ± 0.04 for the FS-LASIK group, respectively. The proportions of all patients with imbalanced vision at 0.4 m, 0.8 m, and 5 m distances were 68.89, 71.11, and 82.22%, respectively (all p > 0.05 between the two groups). There were significant differences in refraction between the balanced and imbalanced vision for patients at 0.4 m distance (for non-dominant eye spherical equivalent [SE]: -1.14 ± 0.17D and -1.47 ± 0.13D, p < 0.001), 0.8 m distance (for preoperative ADD:0.90 ± 0.17D and 1.05 ± 0.11D, p = 0.041), and 5 m distance (for non-dominant SE: -1.13 ± 0.33D and -1.42 ± 0.11D, p < 0.001).ConclusionICL V4c implantation and FS-LASIK monovision treatment demonstrated good long-term safety and binocular visual acuity at various distances. After the procedure, the imbalanced patients' vision is primarily related to the age-related presbyopia and anisometropia progression caused by the monovision design.

Dataset Information

A four-year observation of corneal densitometry after implantable collamer lens V4c implantation.

Background

Methods

Results

Conclusions

Publications

A four-year observation of corneal densitometry after implantable collamer lens V4c implantation.

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