Dataset Information

Multimodal Routing: Improving Local and Global Interpretability of Multimodal Language Analysis.

ABSTRACT: The human language can be expressed through multiple sources of information known as modalities, including tones of voice, facial gestures, and spoken language. Recent multimodal learning with strong performances on human-centric tasks such as sentiment analysis and emotion recognition are often black-box, with very limited interpretability. In this paper we propose Multimodal Routing, which dynamically adjusts weights between input modalities and output representations differently for each input sample. Multimodal routing can identify relative importance of both individual modalities and cross-modality features. Moreover, the weight assignment by routing allows us to interpret modality-prediction relationships not only globally (i.e. general trends over the whole dataset), but also locally for each single input sample, mean-while keeping competitive performance compared to state-of-the-art methods.

SUBMITTER: Tsai YH

PROVIDER: S-EPMC8106385 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:Purpose Manually identifying geographic atrophy (GA) presence and location on OCT volume scans can be challenging and time consuming. This study developed a deep learning model simultaneously (1) to perform automated detection of GA presence or absence from OCT volume scans and (2) to provide interpretability by demonstrating which regions of which B-scans show GA. Design Med-XAI-Net, an interpretable deep learning model was developed to detect GA presence or absence from OCT volume scans using only volume scan labels, as well as to interpret the most relevant B-scans and B-scan regions. Participants One thousand two hundred eighty-four OCT volume scans (each containing 100 B-scans) from 311 participants, including 321 volumes with GA and 963 volumes without GA. Methods Med-XAI-Net simulates the human diagnostic process by using a region-attention module to locate the most relevant region in each B-scan, followed by an image-attention module to select the most relevant B-scans for classifying GA presence or absence in each OCT volume scan. Med-XAI-Net was trained and tested (80% and 20% participants, respectively) using gold standard volume scan labels from human expert graders. Main Outcome Measures Accuracy, area under the receiver operating characteristic (ROC) curve, F1 score, sensitivity, and specificity. Results In the detection of GA presence or absence, Med-XAI-Net obtained superior performance (91.5%, 93.5%, 82.3%, 82.8%, and 94.6% on accuracy, area under the ROC curve, F1 score, sensitivity, and specificity, respectively) to that of 2 other state-of-the-art deep learning methods. The performance of ophthalmologists grading only the 5 B-scans selected by Med-XAI-Net as most relevant (95.7%, 95.4%, 91.2%, and 100%, respectively) was almost identical to that of ophthalmologists grading all volume scans (96.0%, 95.7%, 91.8%, and 100%, respectively). Even grading only 1 region in 1 B-scan, the ophthalmologists demonstrated moderately high performance (89.0%, 87.4%, 77.6%, and 100%, respectively). Conclusions Despite using ground truth labels during training at the volume scan level only, Med-XAI-Net was effective in locating GA in B-scans and selecting relevant B-scans within each volume scan for GA diagnosis. These results illustrate the strengths of Med-XAI-Net in interpreting which regions and B-scans contribute to GA detection in the volume scan.

Dataset Information

Multimodal Routing: Improving Local and Global Interpretability of Multimodal Language Analysis.

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