Effectiveness and Safety of COPD Maintenance Therapy with Tiotropium/Olodaterol versus LABA/ICS in a US Claims Database.

ABSTRACT:

Introduction

In patients with chronic obstructive pulmonary disease (COPD), treatment with long-acting muscarinic antagonist (LAMA)/long-acting β₂-agonist (LABA) combination therapy significantly improves lung function versus LABA/inhaled corticosteroid (ICS). To investigate whether LAMA/LABA could provide better clinical outcomes than LABA/ICS, this non-interventional database study assessed the risk of COPD exacerbations, pneumonia, and escalation to triple therapy in patients with COPD initiating maintenance therapy with tiotropium/olodaterol versus any LABA/ICS combination.

Methods

Administrative healthcare claims and laboratory results data from the US HealthCore Integrated Research Database^sm were evaluated for patients with COPD initiating tiotro

SUBMITTER: Quint JK 

PROVIDER: S-EPMC8107175 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature