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Gene-Environment Interaction in the Era of Precision Medicine.

ABSTRACT: Innovative analytical frameworks are required to capture the complex gene-environment interactions. We investigate the insufficiency of commonly used models for disease genome analysis and suggest considering genetic interactions in complex diseases. For non-genetic factors, we study the emerging wearable technologies that have enabled quantification of physiological and environmental factors at an unprecedented breadth and depth. We propose a Bayesian framework to hierarchically model personalized gene-environmental interaction to enable precision health and medicine.

SUBMITTER: Li J 

PROVIDER: S-EPMC8108774 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Gene-Environment Interaction in the Era of Precision Medicine.

Li Jingjing J   Li Xiao X   Zhang Sai S   Snyder Michael M  

Cell 20190301 1

Innovative analytical frameworks are required to capture the complex gene-environment interactions. We investigate the insufficiency of commonly used models for disease genome analysis and suggest considering genetic interactions in complex diseases. For non-genetic factors, we study the emerging wearable technologies that have enabled quantification of physiological and environmental factors at an unprecedented breadth and depth. We propose a Bayesian framework to hierarchically model personali  ...[more]

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