Unknown

Dataset Information

0

Single-pill combination of telmisartan/amlodipine in patients with severe hypertension: results from the TEAMSTA severe HTN study.


ABSTRACT: This 8-week, randomized, double-blind, controlled study compared efficacy and tolerability of telmisartan/amlodipine (T/A) single-pill combination (SPC) vs the respective monotherapies in 858 patients with severe hypertension (systolic/diastolic blood pressure [SBP/DBP] ≥180/95 mm Hg). At 8 weeks, T/A provided significantly greater reductions from baseline in seated trough cuff SBP/DBP (-47.5 mm Hg/-18.7 mm Hg) vs T (P<.0001) or A (P=.0002) monotherapy; superior reductions were also evident at 1, 2, 4, and 6 weeks. Blood pressure (BP) goal and response rates were consistently higher with T/A vs T or A. T/A was well tolerated, with less frequent treatment-related adverse events vs A (12.6% vs 16.4%) and a numerically lower incidence of peripheral edema and treatment discontinuation. In conclusion, treatment of patients with substantially elevated BP with T/A SPCs resulted in high and significantly greater BP reductions and higher BP goal and response rates than the respective monotherapies. T/A SPCs were well tolerated.

SUBMITTER: Neutel JM 

PROVIDER: S-EPMC8108787 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC3606043 | biostudies-literature
| S-EPMC8108958 | biostudies-literature
| S-EPMC5446818 | biostudies-literature
| S-EPMC4115183 | biostudies-literature
| S-EPMC8673089 | biostudies-literature
| S-EPMC3979648 | biostudies-literature
| S-EPMC5339800 | biostudies-literature
| S-EPMC10567848 | biostudies-literature
| S-EPMC8630602 | biostudies-literature
| S-EPMC5484387 | biostudies-literature