Pentraxin-3-mediated complement activation in a swine model of renal ischemia/reperfusion injury.

ABSTRACT: Pentraxins are a family of evolutionarily conserved pattern recognition molecules with pivotal roles in innate immunity and inflammation, such as opsonization of pathogens during bacterial and viral infections. In particular, the long Pentraxin 3 (PTX3) has been shown to regulate several aspects of vascular and tissue inflammation during solid organ transplantation. Our study investigated the role of PTX3 as possible modulator of Complement activation in a swine model of renal ischemia/reperfusion (I/R) injury. We demonstrated that I/R injury induced early PTX3 deposits at peritubular and glomerular capillary levels. Confocal laser scanning microscopy revealed PTX3 deposits co-localizing with CD31⁺ endothelial cells. In addition, PTX3 was associated with infiltrating macrophages

SUBMITTER: Divella C 

PROVIDER: S-EPMC8109140 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature