[Exploring the therapeutic mechanism of Simiao pills for hyperuricemia based on network pharmacology and molecular docking].

ABSTRACT:

Objective

To explore the mechanism of Simiao pills for treatment of hyperuricemia based on network pharmacology and molecular docking.

Objective

The active ingredients of Simiao pills and their targets of action were predicted using TCMSP, SEA, Swiss and PharmMapper databases. GeneCards and TCD databases were searched for the disease targets related to hyperuricemia. Cytoscape 3.6.1 was used to construct a protein-protein interaction network. GO enrichment analysis and KEGG pathway analysis were carried out on the STRING platform. The binding between the main compounds and the key targets were predicted using the SwissDock platform for molecular docking.

Objective

We identified 28 active ingredients and 429 potential targets in Simiao pills, 494 d

SUBMITTER: Zeng L 

PROVIDER: S-EPMC8110457 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature