Similar glycaemic control and risk of hypoglycaemia with patient- versus physician-managed titration of insulin glargine 300 U/mL across subgroups of patients with T2DM: a post hoc analysis of ITAS.

ABSTRACT:

Aims

The Italian Titration Approach Study (ITAS) demonstrated comparable HbA_1c reductions and similarly low hypoglycaemia risk at 6 months in poorly controlled, insulin-naïve adults with T2DM who initiated self- or physician-titrated insulin glargine 300 U/mL (Gla-300) in the absence of sulphonylurea/glinide. The association of patient characteristics with glycaemic and hypoglycaemic outcomes was assessed.

Methods

This post hoc analysis investigated whether baseline patient characteristics and previous antihyperglycaemic drugs were associated with HbA_1c change and hypoglycaemia risk in patient- versus physician-managed Gla-300 titration.

Results

HbA_1c change, incidence of hypoglycaemia (any type) and nocturnal rates were comparable bet

SUBMITTER: Giaccari A 

PROVIDER: S-EPMC8110495 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature