Characterization of the plasma proteomic profile of frailty phenotype.
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ABSTRACT:
SUBMITTER: Landino K
PROVIDER: S-EPMC8110642 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
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Characterization of the plasma proteomic profile of frailty phenotype.
Landino Kristina K Tanaka Toshiko T Fantoni Giovanna G Candia Julián J Bandinelli Stefania S Ferrucci Luigi L
GeroScience 20201117 2
Frailty is a risk factor for poor health outcomes in older adults. The aim of this study was to identify plasma proteomic biomarkers of frailty in 752 men and women older than 65 years of age from the InCHIANTI study. One thousand three hundred one plasma proteins were measured using an aptamer-based assay. Associations of each protein with frailty status were assessed using logistic regression and four proteins creatine kinase M-type (CKM), B-type (CKB), C-X-C motif chemokine ligand 13 (CXCL13) ...[more]
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