Engineered Biosynthesis of Fungal 4-Quinolone Natural Products.
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ABSTRACT: Quinolone-containing natural products are widely found in bacteria, fungi, and plants. The fungal quinolactacins, which are N-methyl-4-quinolones, display a wide spectrum of biological activities. Here we uncovered a concise nonribosomal peptide synthetase pathway involved in quinolactacin A biosynthesis from Penicillium by using heterologous reconstitution and in vitro enzymatic synthesis. The N-desmethyl analog of quinolactacin A was accessed through the construction of a hybrid bacterial and fungi pathway in the heterologous host.
SUBMITTER: Liu M
PROVIDER: S-EPMC8110742 | biostudies-literature |
REPOSITORIES: biostudies-literature
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