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Discontinuous epidemic transition due to limited testing.

ABSTRACT: High impact epidemics constitute one of the largest threats humanity is facing in the 21^st century. In the absence of pharmaceutical interventions, physical distancing together with testing, contact tracing and quarantining are crucial in slowing down epidemic dynamics. Yet, here we show that if testing capacities are limited, containment may fail dramatically because such combined countermeasures drastically change the rules of the epidemic transition: Instead of continuous, the response to countermeasures becomes discontinuous. Rather than following the conventional exponential growth, the outbreak that is initially strongly suppressed eventually accelerates and scales faster than exponential during an explosive growth period. As a consequence, containment measures either suffice to stop the outbreak at low total case numbers or fail catastrophically if marginally too weak, thus implying large uncertainties in reliably estimating overall epidemic dynamics, both during initial phases and during second wave scenarios.

SUBMITTER: Scarselli D

PROVIDER: S-EPMC8110767 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature

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Discontinuous epidemic transition due to limited testing.

Scarselli Davide D Budanur Nazmi Burak NB Timme Marc M Hof Björn B

Nature communications 20210510 1

High impact epidemics constitute one of the largest threats humanity is facing in the 21<sup>st</sup> century. In the absence of pharmaceutical interventions, physical distancing together with testing, contact tracing and quarantining are crucial in slowing down epidemic dynamics. Yet, here we show that if testing capacities are limited, containment may fail dramatically because such combined countermeasures drastically change the rules of the epidemic transition: Instead of continuous, the resp ...[more]

PMID: 33972522

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