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Presumptive hemophagocytic syndrome associated with immune-mediated anemia in two Miniature Dachshunds.

ABSTRACT: This report describes the cases of two Miniature Dachshunds who were suspected to have immune-mediated hemolytic anemia (IMHA) and were treated with immunosuppressive therapy. However, progression of anemia, increases in C-reactive protein (CRP) and total-bilirubin (T-Bil) levels, splenomegaly, transition to nonregenerative anemia, and thrombocytopenia occurred after the treatment. Splenectomy and bone-marrow aspirations were performed subsequently. Both dogs were diagnosed with hemophagocytic syndrome (HPS) associated with IMHA. Unfortunately, they died 9 and 6 days later. These findings indicate that some cases of refractory IMHA have the pathogenicity of HPS. HPS should be included as a differential diagnosis of refractory IMHA concurrent with thrombocytopenia. Continuously elevated CRP and T-Bil levels may be helpful indicators in the detection of HPS associated with IMHA.

SUBMITTER: Akiyoshi M

PROVIDER: S-EPMC8111343 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature

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Presumptive hemophagocytic syndrome associated with immune-mediated anemia in two Miniature Dachshunds.

Akiyoshi Makoto M Hisasue Masaharu M Neo Sakurako S Akiyoshi Masami M

The Journal of veterinary medical science 20210311 4

This report describes the cases of two Miniature Dachshunds who were suspected to have immune-mediated hemolytic anemia (IMHA) and were treated with immunosuppressive therapy. However, progression of anemia, increases in C-reactive protein (CRP) and total-bilirubin (T-Bil) levels, splenomegaly, transition to nonregenerative anemia, and thrombocytopenia occurred after the treatment. Splenectomy and bone-marrow aspirations were performed subsequently. Both dogs were diagnosed with hemophagocytic s ...[more]

PMID: 33692231

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