Ontology highlight
ABSTRACT:
SUBMITTER: Libura M
PROVIDER: S-EPMC8113255 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Libura Marta M Bialopiotrowicz Emilia E Giebel Sebastian S Wierzbowska Agnieszka A Roboz Gail J GJ Piatkowska-Jakubas Beata B Pawelczyk Marta M Gorniak Patryk P Borg Katarzyna K Wojtas Magdalena M Florek Izabella I Matiakowska Karolina K Jazwiec Bozena B Solarska Iwona I Noyszewska-Kania Monika M Piechna Karolina K Zawada Magdalena M Czekalska Sylwia S Salamanczuk Zoriana Z Karabin Karolina K Wasilewska Katarzyna K Paluszewska Monika M Urbanowska Elzbieta E Gajkowska-Kulik Justyna J Semenczuk Grazyna G Rybka Justyna J Wrobel Tomasz T Ejduk Anna A Kata Dariusz D Grosicki Sebastian S Robak Tadeusz T Pluta Agnieszka A Kominek Agata A Piwocka Katarzyna K Pyziak Karolina K Sroka-Porada Agnieszka A Wrobel Anna A Przybylowicz Agnieszka A Wojtaszewska Marzena M Lewandowski Krzysztof K Gil Lidia L Piekarska Agnieszka A Knopinska Wanda W Bolkun Lukasz L Warzocha Krzysztof K Kuliczkowski Kazimierz K Sacha Tomasz T Basak Grzegorz G Jedrzejczak Wieslaw Wiktor WW Holowiecki Jerzy J Juszczynski Przemysław P Haus Olga O
Scientific reports 20210511 1
Mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) genes occur in about 20% patients with acute myeloid leukemia (AML), leading to DNA hypermethylation and epigenetic deregulation. We assessed the prognostic significance of IDH1/2 mutations (IDH1/2<sup>+</sup>) in 398 AML patients with normal karyotype (NK-AML), treated with daunorubicine + cytarabine (DA), DA + cladribine (DAC), or DA + fludarabine. IDH2 mutation was an independent favorable prognostic factor for 4-year overall survival (OS ...[more]