Ontology highlight
ABSTRACT:
SUBMITTER: Sakane A
PROVIDER: S-EPMC8113518 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Sakane Ayuko A Yano Taka-Aki TA Uchihashi Takayuki T Horikawa Kazuki K Hara Yusuke Y Imoto Issei I Kurisu Shusaku S Yamada Hiroshi H Takei Kohji K Sasaki Takuya T
Communications biology 20210511 1
Elongated tubular endosomes play essential roles in diverse cellular functions. Multiple molecules have been implicated in tubulation of recycling endosomes, but the mechanism of endosomal tubule biogenesis has remained unclear. In this study, we found that JRAB/MICAL-L2 induces endosomal tubulation via activated Rab8A. In association with Rab8A, JRAB/MICAL-L2 adopts its closed form, which functions in the tubulation of recycling endosomes. Moreover, JRAB/MICAL-L2 induces liquid-liquid phase sep ...[more]