TREM2 promotes natural killer cell development in CD3^-CD122⁺NK1.1⁺ pNK cells.

ABSTRACT:

Background

Triggering receptor expressed on myeloid cells 2 (TREM2) signaling is considered to regulate anti-inflammatory responses in macrophages, dendritic cell maturation, osteoclast development, induction of obesity, and Alzheimer's disease pathogenesis. However, little is known regarding the effect of TREM2 on natural killer (NK) cells.

Results

Here, we demonstrated for the first time that CD3^-CD122⁺NK1.1⁺ precursor NK (pNK) cells expressed TREM2 and their population increased in TREM2-overexpressing transgenic (TREM2-TG) mice compared with that in female C57BL/6 J wild type (WT) mice. Both NK cell-activating receptors and NK cell-associated genes were expressed at higher levels in various tissues of TREM2-TG mice than in WT mice. In add

SUBMITTER: Lee HY 

PROVIDER: S-EPMC8114489 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature