Diagnostic biomarkers in tear fluid: from sampling to preanalytical processing.

ABSTRACT: Tear fluid is receiving growing attention as a source for novel diagnostic biomarkers. Multiple techniques are available for its collection and impact the composition of acquired samples. We sought to provide a direct comparison of two collection methods with regard to implementation, acceptance, and impact on sample composition. Tear fluid was collected from fifteen healthy volunteers with capillary tubes and Schirmer strips and analyzed for total protein and IgG concentrations. Sampling parameters and perception by test persons were compared. The use of capillary tubes was more convenient for the participants while causing more effort for the collector. Tear flow rates as well as the relative and absolute amount of IgG were higher when Schirmer strips were used. Consecutive collections w

SUBMITTER: Bachhuber F 

PROVIDER: S-EPMC8114924 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature