Connection Between Chromosomal Location and Function of CtrA Phosphorelay Genes in Alphaproteobacteria.

ABSTRACT: Most bacterial chromosomes are circular, with replication starting at one origin (ori) and proceeding on both replichores toward the terminus (ter). Several studies have shown that the location of genes relative to ori and ter can have profound effects on regulatory networks and physiological processes. The CtrA phosphorelay is a gene regulatory system conserved in most alphaproteobacteria. It was first discovered in Caulobacter crescentus where it controls replication and division into a stalked and a motile cell in coordination with other factors. The locations of the ctrA gene and targets of this response regulator on the chromosome affect their expression through replication-induced DNA hemi-methylation and specific positioning along a CtrA act

SUBMITTER: Tomasch J 

PROVIDER: S-EPMC8116508 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature