Combined ¹⁸F-FET PET and diffusion kurtosis MRI in posttreatment glioblastoma: differentiation of true progression from treatment-related changes.

ABSTRACT:

Background

Radiological differentiation of tumor progression (TPR) from treatment-related changes (TRC) in pretreated glioblastoma is crucial. This study aimed to explore the diagnostic value of diffusion kurtosis MRI combined with information derived from O-(2-[¹⁸F]-fluoroethyl)-l-tyrosine (¹⁸F-FET) PET for the differentiation of TPR from TRC in patients with pretreated glioblastoma.

Methods

Thirty-two patients with histomolecularly defined and pretreated glioblastoma suspected of having TPR were included in this retrospective study. Twenty-one patients were included in the TPR group, and 11 patients in the TRC group, as assessed by neuropathology or clinicoradiological follow-up. Three-dimensional (3D) regions of interest were generated based o

SUBMITTER: D'Amore F 

PROVIDER: S-EPMC8117449 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature