Ontology highlight
ABSTRACT:
SUBMITTER: Traum D
PROVIDER: S-EPMC8119221 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Traum Daniel D Wang Yue J YJ Schwarz Kathleen B KB Schug Jonathan J Wong David Kh DK Janssen Harry LA H Terrault Norah A NA Khalili Mandana M Wahed Abdus S AS Murray Karen F KF Rosenthal Phillip P Ling Simon C SC Rodriguez-Baez Norberto N Sterling Richard K RK Lau Daryl Ty DT Block Timothy M TM Feldman Michael D MD Furth Elizabeth E EE Lee William M WM Kleiner David E DE Lok Anna S AS Kaestner Klaus H KH Chang Kyong-Mi KM
JCI insight 20210408 7
Studies of human hepatitis B virus (HBV) immune pathogenesis are hampered by limited access to liver tissues and technologies for detailed analyses. Here, utilizing imaging mass cytometry (IMC) to simultaneously detect 30 immune, viral, and structural markers in liver biopsies from patients with hepatitis B e antigen+ (HBeAg+) chronic hepatitis B, we provide potentially novel comprehensive visualization, quantitation, and phenotypic characterizations of hepatic adaptive and innate immune subsets ...[more]