Unknown

Dataset Information

0

Ivermectin effectively inhibits hepatitis E virus replication, requiring the host nuclear transport protein importin α1.


ABSTRACT: We show that ivermectin, an FDA-approved anti-parasitic drug, effectively inhibits infection with hepatitis E virus (HEV) genotypes 1 and 3 in a range of cell culture models, including hepatic and extrahepatic cells. Long-term treatment showed no clear evidence of the development of drug resistance. Gene silencing of importin-α1, a cellular target of ivermectin and a key member of the host nuclear transport complex, inhibited viral replication and largely abolished the anti-HEV effect of ivermectin.

SUBMITTER: Li Y 

PROVIDER: S-EPMC8119233 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC3321629 | biostudies-literature
| S-EPMC4684427 | biostudies-literature
| S-EPMC7459547 | biostudies-literature
| S-EPMC138946 | biostudies-literature
| S-EPMC9290431 | biostudies-literature
| S-EPMC7143239 | biostudies-literature
| S-EPMC2966498 | biostudies-literature
| S-EPMC2064387 | biostudies-literature
| S-EPMC6468590 | biostudies-literature
| S-EPMC8054936 | biostudies-literature