Entorhinal cortex and parahippocampus volume reductions impact olfactory decline in aged subjects.

ABSTRACT:

Introduction

Pathological abnormalities first appear in the medial temporal regions including entorhinal cortex and parahippocampus in patients with Alzheimer's disease. Previous studies showed that olfactory decline in elderly subjects was associated with volume reductions in the left hippocampus and left parahippocampus without cognitive impairment. The aim of this study is to investigate the link between olfaction and volume reductions in the medial temporal regions including the parahippocampus, entorhinal cortex, and hippocampal subfields.

Method

27 elderly subjects and 27 young controls were measured olfaction acuity, cognitive function, and structural magnetic resonance imaging. Image processing and gray matter volumetric segmentation were performed with FreeSurfer. V

SUBMITTER: Iizuka N 

PROVIDER: S-EPMC8119819 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature