Dataset Information

High-density lipoprotein cholesterol levels are associated with major adverse cardiovascular events in male but not female patients with hypertension.

ABSTRACT:

Background

The relationship between high-density lipoprotein cholesterol (HDL-C) levels and major adverse cardiovascular events (MACEs) in hypertensive patients of different sexes is unclear.

Hypothesis

Sex differences in the relationship between HDL-C levels and the risk of MACEs among hypertensive patients.

Methods

We performed a post-hoc analysis of data obtained from the Systolic Blood Pressure Intervention Trial (SPRINT) and explored sex-based differences in the relationship between HDL-C levels and MACEs among hypertensive patients using Cox proportional hazards regression.

Results

A total of 9323 hypertensive patients (6016 [64.53%] men and 3307 [35.47%] women) were assessed using SPRINT data. MACEs occurred in 395 (6.57%) men and 166 (5.02%) women after a mean follow-up of 3.26 years. When HDL-C levels were used as a continuous covariate, each 10 mg/dl increase in HDL-C levels decreased the risk of MACEs in men (hazard ratio [HR], 0.78; 95% confidence interval [CI], 0.70-0.88; p < .0001). However, HDL-C levels were not associated with MACEs in female hypertensive patients (HR, 1.02; 95% CI, 0.89-1.16; p = .7869). Compared with those in the first quartile, MACEs in the fourth quartile had the lowest risk among male patients (HR, 0.58; 95% CI, 0.41-0.82; p = .0023). Female patients in the fourth quartile of HDL-C levels had an HR of 1.09 for MACEs (95% CI, 0.62-1.93; p = .7678). HDL-C levels were not associated with the risk of MACEs among females.

Conclusion

Among elderly hypertensive patients, higher HDL-C levels were associated with a lower MACE incidence in men but not in women. Unique identifier: NCT01206062.

SUBMITTER: Wang X

PROVIDER: S-EPMC8119833 | biostudies-literature |

REPOSITORIES: biostudies-literature

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