Alterations of the Human Gut Microbiota in Intrahepatic Cholestasis of Pregnancy.

ABSTRACT:

Background and aims

Women with severe intrahepatic cholestasis of pregnancy (ICP) are at higher risks of fetal complications and without effective treatments. Changes in gut microbiota in pregnancy were found to be related to the altered intestinal bile acid composition, so we aimed to explore the alterations of microbiota in the gut of ICP patients.

Methods

A total of 90 women were recruited, including 45 ICP patients and 45 healthy controls. The gut microbiota communities of ICP group were compared to control group through 16S ribosomal RNA gene sequencing. The results were then confirmed by real-time polymerase chain reaction (PCR) and generalized linear model (GLM). Furthermore, we analyzed the relationships between microbiota and the severity of ICP.

Results

A to

SUBMITTER: Zhan Q 

PROVIDER: S-EPMC8120235 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature