A nomogram incorporating functional and tubular damage biomarkers to predict the risk of acute kidney injury for septic patients.

ABSTRACT:

Background

Combining tubular damage and functional biomarkers may improve prediction precision of acute kidney injury (AKI). Serum cystatin C (sCysC) represents functional damage of kidney, while urinary N-acetyl-β-D-glucosaminidase (uNAG) is considered as a tubular damage biomarker. So far, there is no nomogram containing this combination to predict AKI in septic cohort. We aimed to compare the performance of AKI prediction models with or without incorporating these two biomarkers and develop an effective nomogram for septic patients in intensive care unit (ICU).

Methods

This was a prospective study conducted in the mixed medical-surgical ICU of a tertiary care hospital. Adults with sepsis were enrolled. The patients were divided into development and validation cohorts in c

SUBMITTER: Ma J 

PROVIDER: S-EPMC8120900 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature