Ontology highlight
ABSTRACT:
SUBMITTER: Clark JT
PROVIDER: S-EPMC8121546 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Clark Joseph T JT Christian David A DA Gullicksrud Jodi A JA Perry Joseph A JA Park Jeongho J Jacquet Maxime M Tarrant James C JC Radaelli Enrico E Silver Jonathan J Hunter Christopher A CA
eLife 20210430
IL-33 is an alarmin required for resistance to the parasite <i>Toxoplasma gondii</i>, but its role in innate resistance to this organism is unclear. Infection with <i>T. gondii</i> promotes increased stromal cell expression of IL-33, and levels of parasite replication correlate with release of IL-33 in affected tissues. In response to infection, a subset of innate lymphoid cells (ILC) emerges composed of IL-33R<sup>+</sup> NK cells and ILC1s. In <i>Rag1<sup>-/-</sup></i>mice, where NK cells and ...[more]