Ontology highlight
ABSTRACT:
SUBMITTER: Fujino S
PROVIDER: S-EPMC8121855 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Fujino Shiki S Miyoshi Norikatsu N Ito Aya A Yasui Masayoshi M Matsuda Chu C Ohue Masayuki M Uemura Mamoru M Mizushima Tsunekazu T Doki Yuichiro Y Eguchi Hidetoshi H
Scientific reports 20210514 1
POU5F1-expressing cells can self-renew and differentiate, contributing to metastasis formation in colorectal cancer (CRC), but it plays an important role in normal pluripotent stem cells. Here, we identified the CRC-specific gene, HNF1A, which is the downstream of POU5F1. HNF1A associates with fatty acid and glucose metabolism, and CRC cells highly expressed it. In 198 CRC patients, high HNF1A expression was an independent predictor of disease-free (P = 0.031) and overall (P = 0.007) survival. H ...[more]