Salivary Aβ Secretion and Altered Oral Microbiome in Mouse Models of AD.

ABSTRACT:

Background

Beta amyloid (Aβ) peptide containing plaque aggregations in the brain are a hallmark of Alzheimer's Disease (AD). However, Aβ is produced by cell types outside of the brain suggesting that the peptide may serve a broad physiologic purpose.

Objective

Based upon our prior work documenting expression of amyloid β precursor protein (APP) in intestinal epithelium we hypothesized that salivary epithelium might also express APP and be a source of Aβ.

Methods

To begin testing this idea, we compared human age-matched control and AD salivary glands to C57BL/6 wild type, App^NL-G-F , and APP/PS1 mice.

Results

Both male and female AD, App^NL-G-F , and APP/PS1 glands demonstrated robust APP and Aβ immunoreactivity. Female App^NL-G-F

SUBMITTER: Floden AM 

PROVIDER: S-EPMC8122496 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature