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Epstein-Barr virus-positive ulcer in the oral cavity.

ABSTRACT: Epstein-Barr virus-positive ulcer (EBV + U) is a recently reported B cell lymphoproliferative disorder in the oral cavity, oropharynx, gastrointestinal tract and skin, principally in immunosuppressed patients. A 53-year-old female patient with rheumatoid arthritis treated with methotrexate, presenting ulcers of unknown duration on the dorsum and the lateral left border of the tongue. Excisional biopsy, histopathological analysis and histochemical stains for syphilis (Warthin-Starry), mycotic diseases (Grocott silver methenamine), tuberculosis (Ziehl-Neelsen), immunohistochemistry tests for herpesvirus type 8 (CMV), EBV (LMP-1) and DNA extraction for polymerase chain reaction (PCR) assay to CMV, EBV and herpes simplex virus-1 were performed. Posterior to PCR assay, the final diagnosis was EBV + U in the oral cavity. Acyclovir^® was prescribed, showing clinical improvement. A case of EBV + U with clinical characteristics similar to other lesions or conditions has been reported. Special assays are necessary for an accurate diagnosis and treatment.

SUBMITTER: Ramos-Baena JD

PROVIDER: S-EPMC8123244 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Epstein-Barr virus-positive ulcer in the oral cavity.

Ramos-Baena Jose David JD Jacinto-Alemán Luis Fernando LF Leyva-Huerta Elba Rosa ER Portilla-Robertson Javier J

Journal of oral and maxillofacial pathology : JOMFP 20210319 Suppl 1

Epstein-Barr virus-positive ulcer (EBV + U) is a recently reported B cell lymphoproliferative disorder in the oral cavity, oropharynx, gastrointestinal tract and skin, principally in immunosuppressed patients. A 53-year-old female patient with rheumatoid arthritis treated with methotrexate, presenting ulcers of unknown duration on the dorsum and the lateral left border of the tongue. Excisional biopsy, histopathological analysis and histochemical stains for syphilis (Warthin-Starry), mycotic dis ...[more]

PMID: 34083970

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Dataset Information

Epstein-Barr virus-positive ulcer in the oral cavity.

Publications

Epstein-Barr virus-positive ulcer in the oral cavity.

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