Metabolic Signatures Associated with Severity in Hospitalized COVID-19 Patients.

ABSTRACT: The clinical evolution of COVID-19 pneumonia is poorly understood. Identifying the metabolic pathways that are altered early with viral infection and their association with disease severity is crucial to understand COVID-19 pathophysiology, and guide clinical decisions. This study aimed at assessing the critical metabolic pathways altered with disease severity in hospitalized COVID-19 patients. Forty-nine hospitalized patients with COVID-19 pneumonia were enrolled in a prospective, observational, single-center study in Barcelona, Spain. Demographic, clinical, and analytical data at admission were registered. Plasma samples were collected within the first 48 h following hospitalization. Patients were stratified based on the severity of their evolution as moderate (N = 13), severe (N = 10),

SUBMITTER: Marin-Corral J 

PROVIDER: S-EPMC8124482 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature