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New Crystalline Salts of Nicotinamide Riboside as Food Additives.

ABSTRACT: NR+ is a highly effective vitamin B3 type supplement due to its unique ability to replenish NAD+ levels. While NR+ chloride is already on the market as a nutritional supplement, its synthesis is challenging, expensive, and low yielding, making it cumbersome for large-scale industrial production. Here we report the novel crystalline NR+ salts, d/l/dl-hydrogen tartrate and d/l/dl-hydrogen malate. Their high-yielding, one-pot manufacture does not require specific equipment and is suitable for multi-ton scale production. These new NR+ salts seem ideal for nutritional applications due to their bio-equivalence compared to the approved NR+ chloride. In addition, the crystal structures of all stereoisomers of NR+ hydrogen tartrate and NR+ hydrogen malate and a comparison to the known NR+ halogenides are presented.

SUBMITTER: Schabert G

PROVIDER: S-EPMC8125264 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature

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New Crystalline Salts of Nicotinamide Riboside as Food Additives.

Schabert Günter G Haase Robert R Parris Jaclyn J Pala Laura L Hery-Barranco Adrian A Spingler Bernhard B Spitz Urs U

Molecules (Basel, Switzerland) 20210506 9

NR+ is a highly effective vitamin B3 type supplement due to its unique ability to replenish NAD+ levels. While NR+ chloride is already on the market as a nutritional supplement, its synthesis is challenging, expensive, and low yielding, making it cumbersome for large-scale industrial production. Here we report the novel crystalline NR+ salts, d/l/dl-hydrogen tartrate and d/l/dl-hydrogen malate. Their high-yielding, one-pot manufacture does n ...[more]

PMID: 34066468

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